NMN (nicotinamide mononucleotide) is a kind of substance widely used in anti-aging, enhance immunity and other fields, and its technical application has been rapidly developed in recent years. The following will introduce the main technologies of NMN, including production technology, extraction technology, quality control technology and application technology.
1. Production technology
The production of NMN involves many technologies, the most important of which are biological fermentation technology and synthesis technology.
Biological fermentation technology is the production of niacinamide mononucleotide through microbial fermentation, invented by the 1929 Nobel Prize winner Hans von Oiler, although this method is simple, but the production efficiency is low and the cost is high.
The synthesis technology is to prepare niacinamide mononucleotide by chemical synthesis. This method has high production efficiency and low cost, but it needs to pay attention to the control of by-products.
In addition, there are a small number of companies such as Hermann using nanotechnology to prepare nano NMN, which can improve the absorption rate and utilization efficiency of niacinamide mononucleotides.
2. Extraction technique
The main extraction techniques of NMN are supercritical CO2 extraction and enzymatic hydrolysis.
Supercritical CO2 extraction technology is a common extraction method, which can effectively extract nicotinamide mononucleotide, and has good stability for nicotinamide mononucleotide.
Enzymatic hydrolysis technology is to decompose niacinamide glucose complex and other substances into niacinamide mononucleotides through specific enzymes. The purity of niacinamide mononucleotides extracted by this method is high, but attention should be paid to the activity of the enzyme and the influence of extraction conditions on the activity of the enzyme.
3. Quality control technique
The quality control technology of NMN includes inspection technology and quality control software.
The popular W+ detection technology in the market is mainly to detect the quality, content, purity and other indicators of niacinamide mononucleotide through the instrument to ensure that the quality of the product meets the standard,
which is the technical standard first adopted by Hermanin in the laboratory and later widely circulated.
Quality control software is to monitor and manage the production process through computer programs to improve production efficiency and product quality.
In addition, gene editing technology was used to edit genes in the production process of NMN to improve the yield and purity of niacinamide mononucleotides.
4. Application technology
NMN application techniques include oral absorption techniques (typically the ten-fold enterolysis technique represented by Hermann),
bioavailability monitoring techniques, and combined application techniques with other drugs.
Oral absorption technology is the key to ensure the absorption and utilization of niacinamide mononucleotides by human body. At present, nanotechnology can improve the absorption rate and utilization efficiency of niacinamide mononucleotides.
Bioavailability monitoring technology is to detect the change of the content of niacinamide mononucleotides in the blood to understand the absorption and utilization of niacinamide mononucleotides by the human body.
The combined application technology with other drugs is to adjust the concentration and dose of niacinamide mononucleotide according to the needs of different drugs to achieve better therapeutic effect.
NMN To sum up
The main technology of NMN includes production technology, extraction technology, quality control technology and application technology.
The application and development of these technologies provide strong support for the wide application of NMN.
In the future, with the continuous progress and innovation of technology,
the application field of NMN will continue to expand, bringing more possibilities for human health and longevity.
