ergothioneine will reach 2.8 billion, with a CAGR of 38%

The “Hermès” of the antioxidant world, the “big devil” of memory and skin: Ergothioneine will reach a scale of 2.8 billion yuan, with a CAGR of 38%. Southwest University reports the optimal route

Introduction to Ergothioneine

Ergothioneine (EGT) is a rare amino acid with extremely strong antioxidant capacity. Research shows that it has physiological functions such as scavenging free radicals, chelating divalent metal ions, regulating inflammatory factors, and regulating the tumor microenvironment. It widely used in cosmetics, food, health products, medicine and other fields.

Ergothioneine compound information

Ergothioneine Market Scale

According to predictions from research institutions, the global market size of ergothioneine will reach US$40.8 million in 2023 and will reach US$389 million in 2030, with a CAGR of 38%, an astonishing increase.

Ergothioneine Application

In 2014, ergothioneine was included in the “Catalogue of Used Cosmetic Raw Materials” by my country State Food and Drug Administration. Because of its unique antioxidant effect, it is the product of high-end skin care brands Clinique, Estee Lauder, La Mer, and Yuemue. darling.

In February 2015, Tetrahedron, a company headquartered in Paris, France, announced that its ergothioneine product had passed an independent GRAS assessment.

In July 2017, the European Union (EU) 2017/1281 approved L-ergothioneine as a new food ingredient, which can used in dietary supplements. It is 30 mg per day for the general population and 20 mg per day for children over 3 years old. It cannot used for pregnant women and breastfeeding women. Among women. In October of the same year, the European Food Safety Authority (EFSA) adopted the Scientific Opinion on the Safety of L-ergothioneine.

In 2018, (EU) 2018/462 expanded the scope of use of L-ergothioneine. In addition to dietary supplements, it can also be used in ordinary foods such as beverages and cereal bars.

In 2018, the U.S. FDA certified the GRAS status of ergothioneine produced by Blue Califonia through genetically engineered bacterial fermentation. It can used in cakes, biscuits and pastries (including granola bars), coffee, tea, fruit drinks and cider, carbonated soft drinks and other products containing Chocolate candy. The dosage is 5 mg/serving.

In August 2019, ergothioneine once again passed the GRAS certification of the US FDA and can used in general foods.

Ergothioneine regulations clear obstacles, and in addition to the field of cosmetics, especially in the field of food, its application will open up unlimited space for imagination!

Ergothioneine High Yield Process

Enzyme catalyzed production:

At present, the main production method of ergothioneine is based on the Escherichia coli enzyme catalysis method, by adding three amino acid precursors, histidine, methionine, cysteine and cofactors.

Disadvantages of this method:

Limited by the cost of precursor amino acids and enzyme conversion efficiency, it is difficult to significantly reduce production costs.
Escherichia coli endotoxin is always a key issue for consumers to consider

E. coli and yeast fermentation:

At present, the fermentation hosts used in domestic and foreign research mainly include Escherichia coli, Saccharomyces cerevisiae, etc.

Disadvantages of this method:

Escherichia coli has potential safety risks of bacterial endotoxin, and synthetic ergothioneine accumulates intracellularly;
When Saccharomyces cerevisiae synthesizes ergothioneine, only a small amount of the product is secreted out of the cell, and there are problems with downstream fragmentation and complicated extraction and separation processes;
The model chassis cell fermentation process also requires the addition of precursor amino acids and other disadvantages.

De novo biosynthesis of ergothioneine

Recently, the team of Professor Zou Xiang of Southwest University developed a de novo synthesis of ergothioneine using histidine-producing Corynebacterium glutamicum as the chassis and glucose as the only carbon source.

Features of this technology

The host bacteria is Corynebacterium glutamicum, which solves consumers’ concerns about endotoxins.
The ergothioneine synthesis pathway and the multiplex precursor amino acid synthesis pathway are modified through metabolic flow adaptation technology, and ergothioneine is secreted extracellularly.
The AI protein intelligent design method is used to carry out multiple rounds of mutation iterations on key pathway enzymes, greatly improving production efficiency.
New ergothioneine fermentation technology using glucose as the only substrate and without adding any precursor amino acids during the process
New technology for ergothioneine extraction without cell disruption and system integration of green processes.

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Know More

The reported process is currently the most advanced green process in the country that integrates glucose fermentation and extraction systems. According to Professor Zou Xiang, the fermentation level is expected to reach tens of grams or even hundreds of grams in the future.

With the continuous iteration of strains and improvements in fermentation technology, fermentation costs will be greatly reduced in the future. Ergothioneine regulations have cleared obstacles. In addition to the cosmetics field, its application in the food field will open up unlimited imagination. Especially after the cost drops, its application in the animal feed field is also expected to usher in huge development opportunities. Its market size is expected to further expand!

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