Andrew Huberman, associate professor of neurobiology at Stanford University, shares his thoughts on longevity supplements, where he takes NMN, NR, and grape seed extract daily to maintain energy and blood vessel health, but doesn’t think these extend life.
He stresses the importance of physical and mental health fundamentals, including quality sleep, stress management and exercise, and recommends consulting a doctor before using supplements.
Dr. Andrew Huberman, associate professor of neurobiology and ophthalmology at Stanford University, offered his latest thoughts on longevity supplements in the Huberman Lab podcast. China NMN manufacturers
In the podcast, he revealed that he takes one to two grams of sublingual NMN (which dissolves under the tongue) and 500 milligrams of NR daily to maintain sustained physical energy and mental focus throughout the day.
He also takes 400 to 800 mg of grape seed extract daily because of its potential to improve blood vessel function and blood flow.
Dr. Huberman does not take any of these supplements to extend life because he believes there is a lack of evidence to support any extension of life, at least in humans.
In addition, Dr. Huberman does not take the diabetes drug metformin or rapamycin, a drug approved for transplant to prevent tissue rejection.
Although some people have repurposing these drugs, Dr. Huberman said, they have the potential to extend life. Weighing their benefits has not convinced him.
Dr. Huberman takes NAD+ boosters to improve mental and physical energy
Instead of taking NAD+ boosters NMN and NR for extended life benefits,
he accepts them because they give him a lot of sustained physical and cognitive energy throughout the day.
He also noted that elevated energy levels of these two compounds are gradually reduced during the night.
The Doctor. Huberman added that he had not taken NMN and NR for some time and found that his energy levels had decreased during this time.
In light of NAD+ precursors and longevity, Dr. Huberman said, “I’m not taking NR and NMN to extend my life.
In fact, at this point in history, it is unclear,
and it seems unlikely that increasing NAD + (with NR and NMN) would extend lifespan.
Interestingly, Dr. Huberman said, in the future there may be data showing that NMN and/or NR can extend human lifespan.
However, that data is not here, at least not yet.
Grape seed extract promotes vascular health and blood flow
The naturally occurring plant-derived compound resveratrol is highly touted as a potential anti-aging supplement that can also extend life.
However, Dr. Huberman says it’s fair to say that most of this thinking has been “debunked.”
He added that while resveratrol may have some positive effects on our cells,
there is little clear evidence that resveratrol extends lifespan.
Meanwhile, Dr. Huberman adds that he takes grape seed extract,
which contains a fair amount of resveratrol, because of its potential to enhance vascular health and blood flow.
In addition, he said he needed the compound because of its low cost and because he believed it was safe to use.
Alternative to NMN and/or NR – NAD+ infusion
As a more expensive and inconvenient but potentially more effective alternative to NMN and/or NR, Dr. Huberman communicated about NAD+ infusions.
He says some companies will come to your home or have you go to an institution to give you an infusion of NAD+.
Such procedures use an intravenous (IV) infusion containing NAD+. Along these lines, Dr. Huberman has in the past chosen to take 500 to 1,000 mg of NAD+ by infusion.
In fact, he says he receives these infusions several times a year.
He added that undergoing the procedure was quite uncomfortable, triggering nausea and gastrointestinal discomfort.
In that regard, many people who receive NAD+ infusions take anti-nausea medications.
When Dr. Huberman received the NAD+ infusion, he was not taking anti-nausea medications.
Unsurprisingly, he experienced severe nausea and also felt someone step on his chest and legs.
However, after these side effects subsided, Dr. Huberman said he felt “amazing” and energetic.
Dr. Huberman does not take metformin or rapamycin, two potential life-extending compounds
Dr. Huberman relayed that he does not take the diabetes drug metformin,
which some people have repurposing for possible age-delaying benefits.
Dr. Huberman said he didn’t think there was any convincing evidence that metformin extended life.
He came to this conclusion after reviewing data from Dr. Peter Attia’s metformin study.
Dr. Huberman also does not take the drug rapamycin, a drug approved to prevent tissue rejection in transplant recipients,
some of which have been repurveyor for potential longevity benefits.
He does not accept it because, in his opinion, the current data do not justify the extension of service life.
First address the basics of physical and mental health by choosing supplements
As far as supplements go, Dr. Huberman says you should not consider using supplements for physical and mental health until you’ve addressed the basics of promotion.
He covers some of the basic practices of quality living including getting enough quality sleep.
He also emphasizes stress management and strong social relationships.
In addition, Dr. Huberman said, there is no known longevity of supplement exercise that comes close to providing regular longevity benefits.
Along these lines, Dr. Huberman recommends at least 180 to 220 minutes a week of moderate-intensity cardiovascular exercise,
such as brisk walking, and you can still carry on a conversation.
In addition, he recommends getting your heart rate close to its maximum at least once a week.
In addition, he recommends that six people perform weight lifting or bodyweight resistance training to exercise each part of the body each week in groups of number to enhance the binding connections between nerves and muscles, which may have a positive impact on cognition.
Importantly, the last thing Dr. Huberman stresses is to consult a doctor before adding any supplements to your repertoire.
Therefore, this will help ensure that you receive proper medical guidance related to any possible effects of adverse reactions.
