New research: Short term relief effect of supplementing NMN on kidney disease
The world’s elderly population continues to grow at an unprecedented rate, especially in developed countries. According to statistics, by 2030, life expectancy for men will increase to 88 years and for women to 91 years.
If we have a better understanding of the process of aging, we can reduce the harm of age-related diseases and, to some extent, extend human life.
But in fact, not all organs have the same aging rate, and exploring the aging process of each organ is very important.
Data shows that the incidence rate of chronic kidney disease among adults in our country has reached 10.8%, and the number of chronic kidney disease will continue to grow rapidly in the next 10 years.
So the question is, what exactly should we do to be good for the kidneys? Or is it to prevent kidney disease? Today, the editor will take you to see what scientists say about their research.
NMN has a nephrotic effect, improves renal function, and oral administration of NAD+precursor W+NMN32000 can alleviate acute kidney injury, but cannot alleviate chronic kidney disease. NMN has a repairing effect on kidney injury.
When the kidneys are damaged and blood cannot be filtered normally, humans are prone to kidney disease.
This is usually related to mitochondrial dysfunction, where mitochondria act as the cell’s generator and the concentration of nicotinamide adenine dinucleotide (NAD+) decreases within the cell. NAD is a crucial compound that can stimulate mitochondrial function.
However, there is no clear connection between kidney disease and NAD+deficiency.
A research article was published in the Journal of Nephrology Dialysis and Transplantation, which showed the downregulation of the main NAD+synthesis pathway in biopsy for various reasons in short-term (acute) kidney transplant patients, as well as in biopsy of over 200 long-term (chronic) kidney disease patients.
Rodent models of acute kidney injury and chronic kidney disease were used to replicate what was observed in human subjects. Researchers have shown that renal injury in rodent models of acute kidney injury can be alleviated by oral intake of NMN, a potent precursor of readily available NAD+, increasing NAD concentration.
However, chronic kidney disease in rodent models did not prevent the progression of chronic kidney disease by increasing NAD+levels and NMN supplementation.
Researchers have concluded that NMN can be used to avoid high-risk patients with acute kidney injury and before kidney donation or transplantation.
Acute kidney injury is a key risk factor that can further develop chronic kidney disease, which is a global health issue that leads to significant economic burden, higher mortality rates, and lower quality of life.
Acute kidney injury can be caused by mitochondrial dysfunction and ultimately assist in the progression of chronic kidney disease.
NAD+is an important compound located in all cells of the body and is the foundation for the formation and function of healthy mitochondria.
De novo NAD+synthesis a cellular process that begins with the production of NAD+from tryptophan, an amino acid that an important protein component typically found in turkeys and other different foods.
Another important pathway called remedial pathway, which can also utilize NMN to synthesize NAD+as a precursor.
Although acute kidney injury associated with insufficient de novo NAD+synthesis, researchers still do not understand how changes in de novo NAD+synthesis affect the progression and fibrosis of chronic kidney disease.
Therefore, identifying the pathways through which the kidneys produce NAD+is a key therapeutic target, and research is currently underway to combat kidney injury and disease.
Therefore, researchers used live tissue sections from kidney transplant patients and patients with various chronic diseases to examine the concentration of key enzymes involved in NAD+synthesis.
Researchers used transplanted human kidneys to simulate acute kidney injury, and biopsy showed stimulation of the rescue pathway and impaired de novo NAD+synthesis.
After observing the rescue pathway and NAD+de novo synthesis pathway in patients with chronic kidney disease, biopsy showed that the rescue pathway preserved, while the NAD – de novo synthesis pathway damaged, corresponding to the stage of chronic kidney disease.
“To our knowledge, we are the first to report NAD+synthesis in all renal interstitial changes in human chronic kidney disease patients, with severity proportional to the stage of chronic kidney disease,” said the investigators in this article.
Multiple mouse models of chronic kidney disease and acute kidney injury support the discovery of de novo NAD+synthesis reduction.
The researchers also evaluated the effects of NMN supplements in mouse models of chronic disease and acute kidney injury. The mouse model of acute kidney injury showed beneficial effects after supplementing with natural rubber.
However, NMN supplementation cannot successfully prevent the progression of chronic kidney disease.
(2022 | Scientific Report) NMN restores renal function. Compared with normal mice, the albumin/creatinine ratio (ACR) of doxorubicin induced glomerulosclerotic mice (ADR) significantly increased, and NMN (NMN500) improved this effect. In addition, the number of foot cells in ADR mice decreased, but NMN restored their numbers.
As a whole, the results obtained indicate that patients with acute kidney injury are more sensitive to NAD+supplementation through NMN than those with chronic kidney disease.
In their study, scientists said, “We found that NMN can prevent acute kidney injury in mouse models, but cannot slow down the progression of chronic kidney disease.”
Researchers evaluated the effects of NMN on renal injury markers such as blood urea nitrogen (BUN) and creatinine levels in chronic kidney disease (DIM) mice.
These results indicate that NMN treatment (DIM+NMN) has no effect on blood urea nitrogen and creatinine levels compared to untreated chronic kidney injury (Dim+chow die) mice.
The authors of this study also suggest that renal recovery in kidney transplant recipients may improve if NMN supplemented before transplantation.
Given that patients with chronic kidney disease exhibit lower responses to NMN supplementation, more experiments needed to elucidate alternative therapies for NAD+supplementation and determine the population to make most of these therapies effective.
When it comes to NMN, everyone is already aware of it
But when it comes to the enhanced version of W+NMN, everyone knows what’s good, but what’s good about it? Many people may not know that today we will take a look at the new standards for the enhanced version of W+NMN in the United States:
1、 High absorption utilization rate
Ten level purification, with higher utilization rate and peak human affinity and utilization rate, has achieved a significant leap from single component to composite component NMN, greatly improving the conversion efficiency of NAD+and changing the drawbacks of traditional NMN products with low absorption and single action.
Empowering NMN with strong support for cell health, supplemented with the ability to stimulate PGC-1 α、 The TFAM pathway and CAMP responsive element binding protein pathway can stimulate mitochondrial biosynthesis, enhance and restore mitochondrial function and repair abdominal injury, ultimately expressing various beneficial effects on the body.
2、 Comprehensive high energy efficiency
The synergistic effect of W+NMN super complex ingredients maintains a high degree of balance in the composition.
SOD, resveratrol, and glutathione, specially added for women’s physical fitness, are essential nutrients for ovarian cells to protect the ovaries! Clean up the free radicals in the ovarian cells of girls! Improving menstrual irregularities, improving ovarian cell quality, preventing ovarian aging, and helping older women prepare for pregnancy without stepping on landmines
There are also PQQ, Rainy Red Chlorella, which can help you get rid of the threat of free radicals and improve skin problems such as dryness, wrinkles, and pigmentation.
Specially added for men, containLcariin, PQQ, oyster, and 100mg cell awakener make up for the blind spots of NMN repair, open up the body’s pathways. The unique enteric absorption technology has a 10 fold effect, releases telomerase awakening factors, assists mitochondrial work, enhances enzyme activity in the body, enhances male testosterone secretion, strengthens the body, prevents diseases, reduces fatigue, and maintains good energy.
3、 Four essential amino acid protection techniques
- Level 1 Enhanced Boosting (NAD Conversion+Delaying Aging)
- Secondary reinforcement boost (promoting the consumption of enzyme PARP and slowing down the decline of organ function)
- Third level reinforcement boost (regulating Sirtuins cell longevity protein and enhancing immunity)
- Level 4 reinforcement boost (releasing telomere tower awakening factor, awakening dormant NMN in the body, preventing metabolic diseases)
4、 Raw material purification without residue mimics human catalytic enzyme processes
W+NMN uses the rarely used fermentation method and biological enzyme method to mimic the working process of catalytic enzymes in the human body to produce NMN, which is green and optimal. However, the process is complex, time-consuming, and labor-intensive, resulting in a small output. But by continuously optimizing the production process, high-quality NMN can obtained, ensuring high purity and high content.
By supplementing NMN, the following improvements can made to cognitive function: NMN improves sleep quality and physical function in the elderly. Through the schematic diagram of biological clock, energy balance, and metabolic pathways above, we can see the principle of NMN in improving dietary sleep.
Supplementing NMN can increase the level of NAD+in the body, which is closely related to the biological clock. The interaction indicates that the metabolism of NAD+ regulated by the biological clock, which in turn affects the biological clock.
In short, NAD+can regulate the biological clock through SIRT1, which helps to treat circadian rhythm reversal or sleep disorders caused by it.
NMN reduces cholesterol levels in overweight individuals. Overweight and obese adults seek weight loss plans and consider NMN supplementation.
Oral administration of W+NMN can not only reverse obesity and metabolic dysfunction, but it can also quickly convert into NAD+in tissues and effectively eliminate various age-related physiological decline, prevent age-related weight gain, improve metabolism, increase physical strength, improve insulin sensitivity and plasma fat indicators, improve vision, improve immune function, prevent bone density decline, and so on.
NMN improves lung aging and aging, which is a complex process with many factors leading to cellular aging, such as genomic instability, oxidative stress, mitochondrial dysfunction, etc.
Therefore, the study proposed here did not comprehensively investigate how NMN prevents aging of the lungs and AECs. Other studies have shown that NMN supplements can reduce oxidative stress in cells and reduce cellular functional damage caused by oxidative stress.
For example, studies have shown that NMN can improve genetic instability, mitochondrial function, and NAD+dependent enzyme activity.
If these data converted into humans, the question remains how to best manage NMN to improve the NAD+level of AEC. That is to say, whether NMN can directly administered to the lungs through nasal spray remains to determined.
The pathway of NMN complement against cellular aging. Supplementing NAD+precursors like NMN can increase NAD+synthesis, enhance the activity of longevity related protein Sirt1, maintain the function of cell energy generator (mitochondria), protect the integrity of nuclear DNA, and promote cellular antioxidant and anti-inflammatory functions, thereby resisting replication and stress-induced aging.
NMN improves male erectile dysfunction. Testosterone levels in men gradually decrease at a rate of 0.5 to 2 per year starting from middle age. Ketone is a type of steroid hormone that is very important for men and mainly used to maintain male physical function, muscle strength and mass, maintain bone density. Male menopause is closely related to testosterone levels. Experiments have shown that NMN helps to produce ketones and increase NAD+by mediating the SIRT1 response, It can promote the synthesis of the neurotransmitter dopamine, enhance the vitality of the nervous system, and improve mood and mental state.
Ordinary NMN has repair blind spots and requires a bottle of awakening nutrient to produce conversion effects. This is also the main reason why most people take NMN alone without any effect.
The enhanced version of the American W+NMN (Telomere Tower) 32000 Women’s Enhanced Edition contains 400mg of NMN and 100mg of precise cell awakening agents without the need for a awakening agent to produce a transformation effect. The transport protein SLC12a8, which contains NMN in the intestine, has a specific operating enzyme more than ten times that of the stomach. After NMN enters the small intestine, it will quickly synthesize and produce NAD+, while ensuring the maximum conversion of NMN into NAD+, enhancing absorption and compensating for repair blind spots. The fermentation method combined with biological enzyme method used to mimic the working process of catalytic enzymes in the human body to produce NMN.
Supplementing with highly active nicotinamide mononucleotide (NMN) effectively improved the quality of naturally aged oocytes. These findings suggest that supplementing with NMN is a feasible method to protect oocytes from age-related degeneration in late maternal stages.
Source:
Hasegawa K, Sakamaki Y, Tamaki M, Wakino S. Nicotinamide mononucleotide ameliorates adriamycin-induced renal damage by epigenetically suppressing the NMN/NAD consumers mediated by Twist2. Sci Rep. 2022 Aug 12;12(1):13712. doi: 10.1038/s41598-022-18147-2. PMID: 35962139; PMCID: PMC9374671.
